Regulation of porcine circovirus type 2-like particles expressed in baculovirus expression system
نویسندگان
چکیده
منابع مشابه
Comparison of commercial one-dose and two-dose baculovirus-expressed porcine circovirus type 2 subunit vaccines
Porcine circovirus type 2 (PCV2) is a small, non-enveloped, single-stranded DNA virus in the genus Circovirus within the family Circoviridae.1 It has been incriminated as a major causative agent of postweaning multisystemic wasting syndrome (PMWS), which is known as PCV2-associated diseases (PCVAD);2,3 PCVAD is considered to be an economically important global issue. Most Korean swine farms (95...
متن کاملVirus-Like Particles of Chimeric Recombinant Porcine Circovirus Type 2 as Antigen Vehicle Carrying Foreign Epitopes
Virus-like particles (VLPs) of chimeric porcine circovirus type 2 (PCV2) were generated by replacing the nuclear localization signal (NLS; at 1-39 aa) of PCV2 capsid protein (Cap) with classical swine fever virus (CSFV) T-cell epitope (1446-1460 aa), CSFV B-cell epitope (693-716 aa) and CSFV T-cell epitope conjugated with B-cell epitope. The recombinant proteins were expressed using the baculov...
متن کاملImmunology of porcine circovirus type 2 (PCV2).
The emergence of porcine circovirus type 2 (PCV2) associated diseases and particularly postweaning multisystemic wasting syndrome (PMWS) was a shock for the swine industry and formulated a considerable challenge for researchers in the area of viral immunology in swine. The unique features of PMWS of which emaciation and lymphoid depletion were the most evident indicated a deep involvement of th...
متن کاملGenetic Characterization of Porcine Circovirus Type 2 from Pigs with Porcine Circovirus Associated Diseases in Argentina
Porcine circovirus type 2 (PCV-2) has been associated with syndromes grouped by the term porcine circovirus associated diseases (PCVAD). The PCV-2 isolates have been grouped into two major groups or genotypes according to their nucleotide sequence of whole genomes and/or ORF-2: PCV-2b, which have, in turn, been subdivided into three clusters (1A-1C), and PCV-2a, which has been subdivided into f...
متن کاملIn vitro intragenomic rearrangement of porcine circovirus type 2.
We report here for the first time the genome sequence of a rearranged porcine circovirus type 2 (PCV2) strain, CH-IVT1, isolated from PCV2-infected PK-15 cells. The complete circular genome of the CH-IVT1 is 605 nucleotides (nt) in length. The finding will help us to understand the molecular evolution of PCV2 and the relationship between PCV2 and PCV-associated diseases.
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ژورنال
عنوان ژورنال: Bioresources and Bioprocessing
سال: 2016
ISSN: 2197-4365
DOI: 10.1186/s40643-016-0114-8